A qualitative analysis of the factors that protect athletes against doping in sport

Design: Ten competitive athletes (M = 5, F = 5) representing five different sports (field hockey, boxing, football, triathlon, rugby) were recruited through convenience sampling to undertake a semi-structured interview to enable a qualitative analysis of athletes' lifelong athletic careers. Method: Verbatim transcripts were analysed using an established three-stage coding process to identify the common themes within the narratives. Results: Personal and situational protective factors were identified in the accounts. Personal factors included: (i) a strong moral stance against cheating; (ii) an identity beyond sport; (iii) self-control; and (iv) resilience to social group pressures. Situational factors included secure attachments to people at all stages of the athlete's life. This facilitated both the promotion of moral decision making and assisted in the development of anti-doping attitudes. When situational factors – such as a pro-doping climate – arose, key attachments in the athletes' lives interplayed with personal factors to reduce the risk of doping. Conclusions: These findings offer insights into factors that protect competitive athletes against using PEDs in sport and further our understanding of the complex interaction between risk and protective factors at individual, psychosocial and societal levels among competitive athletes. As a complex behaviour, doping in sport cannot be prevented by solely focussing on the individual athlete; contextual factors beyond the athlete's control also impact on this behaviour. Thus, a paradigm shift is warranted to move beyond an athlete-centred approach to anti-doping

Alcaloides de las hojas de Sophora macrocarpa

El alcaloide principal de las hojas de Sophora macrocarpa Sm. es la matrina. También fueron aisladas e identificadas N-metilcitisina y citisina, asi como el N-óxido de matrina y el soforanol ( 5a-hidroximatrina). Los espectros de rmnde 1H a 200M Hz permitieron extender la lista de asignaciones publicadas para estos compuestos

Multimorbidity in patients enrolled in a community-based methadone maintenance treatment programme delivered through primary care

Background: Multimorbidity, the co-existence of two or more (2+) long-term conditions in an individual, is common among problem drug abusers. Objective: To delineate the patterns, multimorbidity prevalence, and disease severity in patients enrolled in a community-based primary care methadone maintenance treatment (MMT) programme. Design: This was a retrospective cohort study (n=274). The comparator group consisted of mainstream primary care patients. Electronic medical record assessment was performed using the Cumulative Illness Rating Scale. Results: Prevalence of multimorbidity across 2+ domains was significantly higher within the MMT sample at 88.7% (243/274) than the comparator sample at 51.8% (142/274), p<0.001. MMT patients were seven times more likely to have multimorbidity across 2+ domains compared with mainstream patients (OR 7.29, 95% confidence interval 4.68–11.34; p<0.001). Prevalence of multimorbidity was consistently high across all age groups in the MMT cohort (range 87.8–100%), while there was a positive correlation with age in the comparator cohort (r=0.29, p<0.001). Respiratory, psychiatric, and hepatic–pancreatic domains were the three most common domains with multimorbidity. Overall, MMT patients (mean±SD, 1.97±0.43) demonstrated significantly higher disease severity than mainstream patients (mean±SD, 1.18±0.78), p<0.001. Prevalence of moderate disease severity observed in the <45-year MMT age group was 50% higher than the ≥45-year comparator age group. Conclusions: Prevalence of multimorbidity and disease severity in MMT patients was greater than in the age- and sex-matched comparators. Patients with a history of drug abuse require co-ordinated care for treatment of their addiction, and to manage and prevent chronic illnesses. Community-based programmes delivered through primary care help fulfil this need.Journal of Comorbidity 2014;4(1):46–5

Calculating invariants as coreflexive bisimulations

Invariants, bisimulations and assertions are the main ingredients of coalgebra theory applied to software systems. In this paper we reduce the first to a particular case of the second and show how both together pave the way to a theory of coalgebras which regards invariant predicates as types. An outcome of such a theory is a calculus of invariants’ proof obligation discharge, a fragment of which is presented in the paper. The approach has two main ingredients: one is that of adopting relations as “first class citizens” in a pointfree reasoning style; the other lies on a synergy found between a relational construct, Reynolds’ relation on functions involved in the abstraction theorem on parametric polymorphism and the coalgebraic account of bisimulations and invariants. This leads to an elegant proof of the equivalence between two different definitions of bisimulation found in coalgebra literature (due to B. Jacobs and Aczel & Mendler, respectively) and to their instantiation to the classical Park-Milner definition popular in process algebra.Partially supported by the Fundacao para a Ciencia e a Tecnologia, Portugal, under grant number SFRH/BD/27482/2006

Search for active-sterile neutrino mixing using neutral-current interactions in NOvA

We report results from the first search for sterile neutrinos mixing with active neutrinos through a reduction in the rate of neutral-current interactions over a baseline of 810 km between the NOvA detectors. Analyzing a 14-kton detector equivalent exposure of 6.05×10^(20) protons-on-target in the NuMI beam at Fermilab, we observe 95 neutral-current candidates at the Far Detector compared with 83.5 ± 9.7(stat) ± 9.4(syst) events predicted assuming mixing only occurs between active neutrino species. No evidence for ν_μ→ν_s transitions is found. Interpreting these results within a 3+1 model, we place constraints on the mixing angles θ_(24) < 20.8° and θ_(34_ < 31.2° at the 90% C.L. for 0.05  eV^2 ≤ Δm^2_(41) ≤ 0.5  eV2, the range of mass splittings that produce no significant oscillations over the Near Detector baseline

Constraints on Oscillation Parameters from ν_e Appearance and ν_μ Disappearance in NOvA

Results are reported from an improved measurement of ν_μ→ν_e transitions by the NOvA experiment. Using an exposure equivalent to 6.05×10^(20) protons on target, 33 ν_e candidates are observed with a background of 8.2±0.8 (syst.). Combined with the latest NOvA ν_μ disappearance data and external constraints from reactor experiments on sin^2 2θ_(13), the hypothesis of inverted mass hierarchy with θ_(23) in the lower octant is disfavored at greater than 93% C.L. for all values of δ_(CP)